Diabetes is a major health problem in India. An estimated 72 million Indians suffer from diabetes and this number is projected to go up in the future. In such a situation, diagnostic test for pre-diabetes can help in controlling the burden of disease through suitable lifestyle modifications.
Scientists from the Pune-based National Chemicals Laboratory (NCL) have found that in pre-diabetes condition, blood has an abundance of glucose bound to units of protein serum albumin. This biological state can be used as biomarker for pre-diabetic condition diagnostic tests.
If prediabetes is not controlled in time it can lead to the development of diabetes and complications in the functioning of blood vessels. In pre-diabetic condition there is an abundance of three specific peptides bound to glucose. This insight, researchers feel, could be used for assessing pre-diabetic state of individuals.
“Currently these peptides are quantified by mass spectrometry, which is relatively less through put and not available in common diagnostic labs. Therefore, we aim to develop specific monoclonal antibodies against these peptides and develop user friendly immunoassay,” Dr. Kulkarni said.