The COVID-19 pandemic in the United States has created a change in the timing and intensity of re-emergent respiratory syncytial virus (RSV) epidemics, depending on the duration of mitigation measures and the extent of virus introduction from other regions. A simulation modeling study, conducted to explore a range of potential scenarios and to better understand the factors linked to RSV epidemics, included the factors that might impact the re-emergence of RSV epidemics such as the introduction of the virus from out-of-state sources and decreased rates of transplacentally acquired immunity in infants. The results of the analysis, published in JAMA Open Network, suggests that pediatric departments need to be alert to large RSV outbreaks in the coming seasons, with the intensity of these epidemics based on the size of the spring and summer epidemics in that location. They recommend enhanced surveillance for both the administration of prophylaxis and the management of hospital capacity.