Biomolecular archaeology has been an emerging field in forensic science. Old skeletal and soft tissue samples can contain remnants of the original bacterial DNA even after long years after their decay. This applies both to the DNA of human commissions (for example, intended intestinal bacteria) and the genetic material of the pathogen. The biomolecular examination of pathogens in the old man remains an emerging research area that offers significant insights into history and evolution of infectious diseases.

In order to further optimize the molecular diagnosis, the Eurac Institute for Mummy Studies approaches access to a variety of tissue samples with possible tuberculosis, brucellose and malaria infection. Together with our cooperation partner from Vienna and Stockholm, we analyze the metagramic data of the genomic ICEMAN survey a bio-informative pipeline for the Novo detection of COMMENSES and pathogens in metagenomic records of old human remains to establish. Biomolecular archeology offers new insights into former civilizations, cultures and practices. Criminology has quickly made progress for exposure and analysis of the smallest DNA traces of DNA due to the new and improved progress methods. Biomolecular archaeology will help a lot in forensic science.

Ironically, similar feelings about the industrial revolution expressed all important changes in the history of humanity, suggesting that the quality of human health and life is initially reduced. Larsen applied biomolecular archeology to fill the holes of these historical shots, which in combination with changes in the diet and the lifestyle, torn and the collapse of the population (Larsen, 2000) has made a more complex image in the disease.  Biomolecular archaeology has been a really new emerging yet very helpful.

 The use of mass spectrometry can demonstrate proteins that have been demonstrated by the use of immunological methods and collins and pistons and colleagues, and the pistons have developed a digital immunoassay milk proteins on ceramic pot making their findings in the dairy in West Scotland led. When it comes to migration and the origin of humans, human DNA still gives some of the best instructions, though researchers also examine viruses and bacteria traveling with their human hosts (Rinaldi, 2007).  Sources like bones or tooth altitude analyzes at these places where you can be found.

 This seems a bit earlier, as originally adopted after the last ice age about 14,000 years ago. 

 Sources of Old biomolecules : Old DNA can be stored in different discrete radicals, as well as a variety of deposit archive (rated in 28). While bone and teeth remain the most commonly used mineralized . Copies for adna, there is a wealth of other suitable calcifications and mineralized substrates, such as eggshells, fluidized shells, coproliters and tartar, the last two are particularly valuable for old microbiomes. Human material, e.g. hair, claws and springs, ensure further important, albeit the relatively rare source of the animal.

A first evaluation of the decay of old proteins can be carried out using sodium dodecyl sulfate (SDS) gel electrophoresis (19, 39).  In contrast to their modern colleagues, Old protein tracts do not produce electrophoretic profiles with different, sought-after tires characteristic of intact, freshly denatured proteins, but a continuous cutting of protein residues. Through spontaneous peptide pressing ridge split and the formation of covalent transversely glands between proteins and possibilities, these may also be used other organic compounds such as carbohydrates and lipids.

 Protein fragment often occurs as a result of the spontaneous enzymatic peptide skeleton cleavage on the carboxyl side of asparagine (ASN) and glutamine (GLN), and such fragmentation correlated with their spontaneous and enzymatic deamidation of aspartic acid (ASP)  and glutamic acid (GLL ) is connected. Peptide Backbone Split also takes place with ASP and

Analysis of old biomolecules:  Each phase of the old biomolecule study requires the approval of dedicated methods that take into the most important properties of old biomolecules. Selection of sample, sample preparation.

Data generation and interpretation must be set to limited quantities, of extended degradation and extensive infection that examined the old biomolecules

Sampling: The two main objectives of the ADNA collection is to Maximize endogenous DNA  content and minimization of contamination. An optimal tremical sample is an important first step from to achieve this. The targeted sampling of the most difficult and closest strongest strongest bone elements  in the mammal skeleton was, for example, a tool for climbing the genomics of the old population.

Extraction: The properties of each sample substrate form specific requirements for the performance of methods of effective digestion of the material and the solubility of the  DNA. For mineralized samples (for example, bones, teeth), this is often done with the help of buffers; Demineralization agent, such as ethylenediamine tetraacetic acid (EDTA); Detergents such as SDS; surfactants such as Nlauroylsarcosin; and proteinases.