Tissue preservation should be considered as endpoint for geographic atrophy therapies
Dr. Klen performed by far the essential component in the creation and the development of Tissue preservation Banking in Europe. His idea of a tissue preservation bank envisaged the storage of all sorts of cells, tissue, and organs that physicians and surgeons would possibly want to treat their patients. There has been a great deal of progress towards this goal, however, still, the very last goal remains elusive.
This overview of the current role starts with the popularity that a few tissues are required to incorporate or encompass cells that showcase all of the formal characteristics of life if they're to function as grafts, while different tissues do not. For a few issues, the protection of mechanical properties is vital: for others, it's far not. These concerns are vital for the layout of protection methods for unique tissues: bone tendon and skin can offer beneficial grafts in the absence of residing cells and this can also be proper for cardiac valves: the vital requirement right here is that the mechanical houses stay intact. Simply freezing at around -80 degrees C can be enough. In contrast, many cell systems, and all metabolizing organs do require healthy cells to function.
Cryopreservation is frequently an effective treatment for remoted cells, for example, hemopoietic stem cells, however, the damaging consequences of the formation of ice are enough to rule out this technique for entire vascularised organs and a few issues too. The unfavorable mechanisms are discussed, and it's far concluded that the site of ice crystallization is vital. Cartilage has hitherto been recalcitrant, however, we have these days evolved a technique that lets this tissue be saved at liquid nitrogen temperatures with no ice and with the restoration of residing cells and intact mechanical houses after storage. Thus, many techniques are to be had to assist expand tissue banking initially anticipated via way of means Dr. Klen.
