Various new ways have been discovered for colorectal cancer. This method, recently detailed in the Journal of the American Chemical Society, uses nanoparticles with a nickel-rich core and a platinum-rich shell to increase the sensitivity of an enzyme-linked immunosorbent assay (ELISA).  ELISA is a test that measures biochemical samples such as antibodies and proteins that can indicate the presence of cancer, HIV, pregnancy, etc. its concentration, the darker the colour, the stronger the concentration.

Tests must be sensitive to avoid false-negative results that could delay treatment or intervention. In a study, researchers found that when nanoparticles were used in place of the usual enzyme used in peroxidase ELISA, the test was 300 times more sensitive for detecting carcinoembryonic antigen, and biomarkers are sometimes used for diagnosis of colorectal cancer. 

 Although the study used a colorectal cancer biomarker, the technique could be used to detect biomarkers for other cancers and diseases, ”said Xiaohu Xia, assistant professor of chemistry at UCF and co-author of the study. Colorectal cancer is the third leading cause of cancer death in the United States, except for some types of skin cancer, and early detection improves treatment outcomes, according to US data.

 The increased sensitivity resulting from tampering with nickel-platinum nanoparticles significantly increases the test’s reaction efficiency, increasing its colour yield and therefore its detection capacity, says Mr Xia. Peroxidases found in horseradish root have been widely used for decades to determine colour in diagnostic tests; However, according to Xia, they have limited reactivity and hence colouration, which is slowing the development of sensitive diagnostic tests. “Modeling” of peroxidase nanoparticles has evolved extensively over the past 10 years, but no product has yet reached the reactivity of the nanoparticles developed by Xia and his team. 

 “This work sets a record for the catalytic performance of mimic peroxidase,” says Xia. “This violates the catalytic efficiency limit of mimetic peroxidase, a longstanding problem in this field.” “This advance is enabling highly sensitive detection of cancer biomarkers with the ultimate goal of saving lives through early cancer detection,” he said. Xia says the next steps in the study are to further refine the technology and apply it to clinical patient samples to study its effectiveness. 

 “We hope that this technology can be used in clinical diagnostic laboratories shortly,” Xia said. Colorectal cancer (CRC) is one of the frequent common cancers in the world. Early diagnosis of colorectal cancer makes treatment easier and increases your chances of survival and recovery. Nanoparticles are widely used to deliver certain drugs that increase the solubility of drugs and reduce their toxicity. And the effective properties of nanoparticles are determined by their surface charge, structure, and interaction with the polymer.

Small molecules of peptides or monoclonal antibodies on the surface of nanoparticles increase the orientation of cancer cells about the nanoparticles regardless of the surface charge of the nanoparticles. Nanoparticles are positive, highly toxic and cause cell death or are quickly eliminated by the kidney or cause embolism. The types of nanoparticles used to diagnose CRC cells include iron oxide, gold, carbon, chitosan, and silica nanoparticles. Gold nanoparticles penetrate at picomolar concentrations and detect CRC cells with a stronger signal. Gold nanoparticles make nanoparticle chemistry more efficient by shrinking cancer vessels.

If gold nanoparticles are conjugated to a short oligomycin, it will increase the activity of the targeted nanoparticles in detecting cancer cells. systemic toxicity, but helps in diagnosis by staining the tumour area, but iron oxide nanoparticles are used as a contrast agent for MRI and early detection of malignant neoplasms and identification of small cancer cells with the least amount of error.  A recent review investigating the effect of gut microbiota on cancer therapy and current gut microbiota approaches to diagnosis of colorectal cancer and its treatment. 

 This study uses nanotechnology to block signals from the gut microbiota to facilitate and improve cancer immunotherapy. Oral autonomous nanoparticle generator based on probiotic spores for cancer treatment.

 Researchers at the University of Arizona Healthcare recently completed a study that could improve the treatment of colon cancer and melanoma with nanotechnology to provide more effective chemotherapy against aggressive tumours. “I have always been interested in the use of innate immunity to fight cancer. To do this safely and effectively, nanotechnology was born due to its ability to improve drug fluidity and therapeutic efficacy, as well as its ability to reduce systemic toxicity. I hope these innovative nano therapies and treatment regimens will help cancer patients fight cancer. efficiently and safely. 

 Immunotherapy enhances the ability of the immune system to fight cancer cells. The immune system also helps the body defend itself. “Thus, this nanotherapeutic platform can enhance the effectiveness of BIC therapy in eliminating a significant proportion of colorectal cancer at an early stage, activating the body’s immunity and preventing it. It is noted that its nanotechnology platform can be used to provide a wide range of cancer treatments and has significant advantages in drug development because it is derived from sphingomyelin, a fatty acid approved by the FDA