New research shows that Mental diseases can associate with increased risk of pulmonary tuberculosis in patients. In studies in Asia, the team found strong evidence that depression and schizophrenia are associated with an increased risk of developing active tuberculosis. Depressed people are 15 to 2.6 times more likely to develop tuberculosis than people without depression, while schizophrenia is associated with a 52% increase in risk and a threefold increase in risk and possibility of getting pulmonary tuberculosis in patients. 

 Further analysis of data from a large study of 242,952 people in low- and middle-income countries also found that people with tuberculosis are three times more likely to develop depression than people with tuberculosis. This highlights the importance of working to tackle the global burden of mental illness and adopt a holistic approach to mental and physical health.

 As the overall incidence of tuberculosis remains high in some populations, there is a growing understanding of mental illness, especially depression, and its role in disease progression. The article is an attempt at a holistic approach to studying the influence of mental illness on the natural course of tuberculosis. To investigate the factors associated with non-compliance in TB patients, with an emphasis on mental illness as the main barrier to compliance, we conducted a systematic review. A systematic overview of epidemiological data and previous medical estimates from a historical point of view, and then theoretical research. Subsequent studies  In New York, hospitals have shown that the incidence of tuberculosis diagnosed with radiographic proposals increased from the first admission to examine radiographic research, stressing the role of infectious agents. The lifetime prevalence of affective disorders in patients with chronic disease ranges from 8.9% to 12.9%, and the 6-month prevalence ranges from 5.8% to 9.4%  

 People believe that tuberculosis in a person always disrupts his physical, mental, economic and social life. The patient’s initial reaction to disclosure was anxiety (50%) and thoughts of suicide (9%). general mental disorders. In addition, active TB has a significant social stigma that causes patients to feel rejected and isolated from friends and family, as well as a lack of knowledge about the disease process. and treatments that can contribute to feelings of helplessness and anxiety. 

 Mood disorders are especially common in patients with tuberculosis compared with patients with other medical diagnoses. Contraindicated due to the possibility of Serotonin syndrome and due to the combination of SSRIs and isoniazid has not been reported. 

 Isoniazid, phenytoin, and carbamazepine chose the benzodiazepine Valproate and galdol. The inhibition of monoamine oxidase and histamine by isoniazid can lead to significant drug interactions. Isoniazid is a biphasic inhibitor of the cytochrome P450 isoenzyme CYP2E1 and increases the hepatotoxicity and CNS toxicity of valproate, as well as the toxicity of galdol. Also taking isoniazid2, over isoniazid. in combination with antidepressants are also at increased risk of pulmonary tuberculosis in patients.

 Despite the therapeutic accessibility and vaccines, the tuberculosis remains around the world a problem of public health. Because this study was a case-control study and not a cohort study, we were unable to establish an association between CMD and tuberculosis. This complex relationship may lead to a poorer prognosis in cases of tuberculosis and exacerbate problems with global tuberculosis control. The overall incidence of pulmonary tuberculosis was 1.16 times higher in the depressed group than in the non-depressed group participants