Medical Therapies for Heart Failure with Reduced Ejection Fraction
Dr. Sachin Thacker
D.N.B. (Medicine),
Consultant Physician, Critical Care Specialist,
J.K. Hospital, Bhuj.
This systematic review aimed to evaluate the economic evaluations (EEs) of guideline-directed medical therapies (GDMTs) for heart failure with reduced ejection fraction (HFrEF). A total of 59 EEs were included, with the Markov model being most commonly used. Most EEs in high-income countries showed novel GDMTs were cost-effective compared to the standard of care. Key factors influencing ICERs included model structures, input parameters, clinical heterogeneity, and country-specific willingness-to-pay thresholds.