This case study examines the unique presentation of a Chinese woman in her late 20s who has been experiencing progressive skin laxity for the past 20 years. The woman initially developed asymptomatic yellowish papules in her flexural areas during early childhood. Over time, her skin sagging worsened, spreading extensively throughout her body. Physical examination revealed thick and leathery skinfolds on various regions such as the neck, axillae, inguinal areas, abdomen, and limbs, accompanied by scattered yellowish papules on the dorsal neck. Interestingly, the patient’s younger sister also developed similar skin symptoms. While the patient had no extracutaneous involvement and was born to healthy nonconsanguineous parents, further investigation revealed coagulation abnormalities. Coagulation-related tests indicated a low clotting activity of factor X and a prolonged prothrombin time. However, other laboratory investigations showed no significant findings. To gain more insight into the condition, a skin biopsy specimen was obtained from the patient’s neck for histopathologic examination. The study aims to shed light on this rare case of progressive skin laxity associated with coagulation abnormalities. The findings from this case can contribute to our understanding of the underlying mechanisms and potential treatment options for similar cases in the future.

To know more: About the original article click here.