The purpose of this study was to see how well a multidomain intervention comprising exercise, cognitive training, and vitamin D supplementation worked for those with moderate cognitive impairment. A total of 175 patients between the ages of 60 and 85 were randomly allocated to one of five groups. The first two groups underwent aerobic and resistance exercise training, as well as computerized cognitive training, with one group additionally receiving vitamin D and the other receiving a placebo. The remaining three groups acted as controls, with either exercise alone or exercise combined with sham cognitive training, with or without vitamin D. The primary endpoint of cognitive improvement was assessed using the ADAS-Cog-13 scale at baseline, six and twelve months later. The findings revealed that, when compared to the control group.

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