A recent study by Cedars-Sinai Medical Center researchers sheds light on how diabetes impacts wound healing in the eye. The researchers discovered two disease-related alterations to the cornea that might cause delayed recovery. The scientists also uncovered three treatment routes that restored wound-healing activity and reversed these alterations. This discovery may open the door for novel diabetic therapies. Diabetes causes unique DNA modifications known as epigenetic alterations, which modify gene expression, according to the findings. Wnt-5a, a signaling molecule involved in corneal wound healing and stem cell activity, was also highlighted in the study. Diabetes medications now mainly target symptoms, leaving molecular and cellular alterations and associated implications unaddressed.

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