Columbia University researchers have created eye drops that may offer a more comfortable and effective treatment for retinal vein occlusion (RVO). The standard therapy involves injecting an inhibitor into the eye, but fear of needles often leads to delayed treatment and poor outcomes. The experimental eye drops were found to be twice as effective at reducing swelling and improving blood flow in mice with RVO, while also preventing deterioration of the retina’s photoreceptors. The treatment involves caspase-9 inhibition, which confers stronger neuronal and vascular protection compared to VEGF neutralization. This new therapy could potentially help more people with RVO, a leading cause of blindness worldwide.

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