A recent study published in Cell Metabolism has shown that proteins and genetic material secreted by fatty liver cells can stimulate the spread of colorectal cancer to the liver. The findings were based on preclinical analyses conducted by an international group of researchers, who observed that extracellular vesicles released by fatty liver cells contained types of RNA that could react with another protein, promoting aggressive cancer that is more likely to metastasize. This process was confirmed in human tissue samples from patients with colorectal cancer who had liver metastases. Ekihiro Seki, MD, PhD, professor of medicine and biomedical sciences at Cedars-Sinai, discussed the results and suggested that a new approach may be required for managing adults with colorectal cancer and fatty liver. Overall, the study highlights the link between lifestyle factors such as diet and the development and progression of cancer.

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