An international research effort led by Queensland Institute of Medical Research (QIMR) Director Berghofer has uncovered hundreds of previously unknown genes connected to the risk of getting glaucoma. This discovery might open the door for the prevention of retinal damage, which leads to blindness. Previously, approximately 100 loci for primary open-angle glaucoma had been found, with two major features related to the condition: intraocular pressure and optic nerve head excavation injury. However, a significant amount of glaucoma heritability remained unexplained, motivating QIMR Berghofer researchers to conduct a large-scale genome-wide association study (GWAS). The study collected data from a variety of sources, including the UK Biobank and the Massachusetts General Brigham Biobank, and genotyped nearly 488,000 subjects using over 800,000 markers. By combining primary open-angle glaucoma with cataract surgery.

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