The study discovered that bladder-sparing trimodal therapy combined with high-dose radiation is a promising therapeutic option for individuals with nonmetastatic clinically node-positive bladder cancer. Out of the 287 patients studied, 87 had radical radiation and 76 had radical cystectomy. Patients who got radical radiation had a median overall survival of 2.53 years, compared to 2.09 years for those who underwent radical cystectomy. There was no statistically significant difference between the two treatment regimens in terms of overall survival or progression-free survival. However, receiving chemotherapy was linked to a higher chance of survival. For patients undergoing radical therapy, neither performance status nor clinical stage upon diagnosis had an influence on survival. Because survival rates were comparable regardless of therapy modality, the researchers concluded that patients who are able should receive drastic treatment.

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