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Inflammatory responses generated in allergic diseases help stop development of skin cancer: Study

A recent study carried out at Tampere University in Finland found that the inflammatory responses generated in allergic diseases such as Asthma, eczema and allergic rhinitis protects the human body against skin cancer. 

The researchers said that their study was carried out on mice to find out that the deficiency of interleukin-13 (IL-13), which generates inflammatory responses like music secretion, led to an increase in the number of immune-suppressing regulatory T cells during the development of skin cancer. The basic findings of the study was that the expression of the IL-13 receptor associated with allergic inflammation protects against experimental skin cancer; the tumors formed earlier and were more abundant in the absence of IL-13Ra1 than in its presence. 

According to the researchers, this finding actually supports the idea that excessive regulatory T-cell activity, by inhibiting the immune response against tumour cells, provides space for cancer to develop. “While the exact mechanism remains unclear, it is clear that when the IL-13 receptor expression on the cell surface is absent during the development of cancer, the number of regulatory T cells increases, and the immune response is suppressed or skewed.”

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