Treatment with isotretinoin in severe acne cases did not show signs of adverse neuropsychiatric impacts compared with antibiotics treatment, suggests a recent study. The research, led by Dr Seena Fazel, a professor of psychiatry at the University of Oxford, and Dr Tapio Paljarvi from the Department of Forensic Psychiatry at the University of Finland, completed a propensity score-matched cohort study of electronic medical records that included 30,866 patients who were prescribed isotretinoin, 44,748 patients prescribed oral antibiotics, 108,367 patients with acne prescribed topical anti-acne medications and 78,666 patients with acne without anti-acne medication. This study, which was conducted in the wake of rising concerns that isotretinoin could have a negative impact on mental health. however, showed that this medication was unlikely to be causing poor mental health.