According to a recent study in the journal Science Translational Medicine, depression that follows a TBI is distinct from other kinds of depression. The researchers suggest a brand-new subgroup called “TBI affective syndrome,” which might influence future treatment options for this mental health disease. Antidepressants and cognitive behavioral therapy, which were often used to treat depression brought on by a TBI, have not always proven successful. Dr. Shan Siddiqi, the study’s principal investigator from Harvard Medical School, thinks that structurally oriented therapies, particularly those involving targeted brain stimulation, would be more effective. The study analyzed brain scans from people with depression following a traumatic brain injury, depression without a traumatic brain injury, and people with and without post-traumatic stress using modern imaging techniques.

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