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Mavacamten Treatment Improves Cardiopulmonary Exercise Testing Parameters: Oxygen Pulse Not Reported

In this context, the authors express their gratitude to van der Stouwe et al for their interest and valuable insights regarding their recent publication. The study findings demonstrated that mavacamten treatment yielded significant enhancements in various cardiopulmonary exercise testing parameters, extending beyond peak oxygen uptake. Notably, it positively impacted measures of maximal exercise capacity and submaximal exertional tolerance. However, the authors acknowledge a point raised by van der Stouwe and colleagues. They noted that the publication did not report on oxygen pulse (O2 pulse), a crucial parameter associated with cardiovascular health and exercise efficiency.  In conclusion, mavacamten treatment has been shown to have a positive impact on cardiopulmonary exercise testing parameters, indicating its potential as a therapeutic option. The study’s limitations include the absence of information on oxygen pulse, an aspect that could further contribute to understanding the treatment’s effects on cardiovascular function during exercise.

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