A meta-analysis of 54,799 people from 17 prospective cohort studies revealed no link between omega-3 fatty acid levels largely acquired from food and the incidence of incident atrial fibrillation (AF). The findings, published in the Journal of the American College of Cardiology, contradict findings from omega-3 fatty acid supplement studies, which revealed that supplementation was associated with an increased risk of AF. The majority of those who took part in the meta-analysis lived in the community and were either free of cardiovascular disease or at low cardiovascular risk. The use of omega-3 fatty acid supplements was uncommon in the cohorts, indicating that biomarker levels generally matched dietary consumption. The researchers believe that randomized controlled studies of high-dose encapsulated omega-3 agents are unlikely to replicate.

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