A secondary analysis of the SWOG S1007 RxPONDER study found that adding regional nodal irradiation (RNI) did not lower locoregional recurrence rates (LRRs) considerably in patients with favorable-risk, node-positive hormone receptor-positive, HER2-negative breast cancer. Patients who had breast-conserving surgery and radiation with RNI had a 5-year LRR of 0.85%, whereas those who had breast-conserving surgery without RNI had a 5-year LRR of 0.55%. Mastectomy with postmastectomy radiation resulted in a 5-year LRR of 0.11%, but mastectomy without radiotherapy resulted in a 5.7% LRR. In both premenopausal and postmenopausal individuals, the presence or absence of RNI had no effect on invasive disease-free survival (iDFS). Tumor size and the number of positive nodes were both predictors of RNI receipt.

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