A recent study published in Clinical Gastroenterology and Hepatology found that a diagnosis of irritable bowel syndrome (IBS) based on Rome IV criteria is safe and durable, with only 1% of patients diagnosed with a different gastrointestinal disease after rereferral and reinvestigation for ongoing IBS symptoms. The study analyzed symptom data from 373 adults who met Rome IV criteria for IBS and were referred for a standardized workup to exclude other diseases. Results showed that even though one in six patients were rereferred, only 1% were diagnosed with an organic gastrointestinal disease subsequently. The authors suggest that physicians should be aware that using an approach of limited investigations combined with the application of recommended diagnostic criteria is a safe strategy for managing IBS in secondary care.