Serum CASC2 can distinguish healthy individuals from children with asthma, suggests a study. The latest research by a team of  scientists at the Department of Paediatrics, Chang ‘an District Hospital, Xi‘an, China, analysed over 70 asthmatic children and 66 healthy controls to find that CASC2 was at a low level in asthmatic children in comparison with healthy controls. The researchers explained that the overexpression of CASC2 inhibited PDGF-BB induced cell proliferation and migration via sponging miR-31-5p. In addition, the researchers also found that LncRNA CASC2 serves as a ceRNA of miR-31-5p, and overexpression of miR-31-5p reversed the influence of CASC2 on asthma in vitro. Therefore, serum CASC2 can be used as a promising biomarker for the onset of asthma by serving as a feasible positive regulator of ASMCs proliferation and migration and a negative mediator for cell inflammation.