Sporadic Creutzfeldt-Jakob Disease (sCJD) is an uncommon neurodegenerative Parkinson’s disease that causes dementia, behavioral abnormalities, and the loss of higher brain functions. Patients frequently have neuromotor symptoms such as ataxia and myoclonus. Very few cases of CJD begin with stroke-like symptoms like one-sided weakness. On MRI, a 56-year-old male patient presented to the stroke unit with left-sided weakness and an acute parietal infarct. His condition deteriorated over four weeks, with diminishing cognition, worsening motor function, sphincter dysfunction, and final death.

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