The guidelines recommend several topical therapies for managing atopic dermatitis in adults. Strong recommendations are made for using moisturizers, topical calcineurin inhibitors, topical corticosteroids, and topical Janus kinase and phosphodiesterase-4 inhibitors. The evidence shows these treatments effectively alleviate symptoms and improve patients’ conditions. Conditional recommendations are given for bathing and wet wrap therapy, though the evidence is not as strong. The guidelines discourage using topical antimicrobials, antiseptics, and antihistamines as the evidence does not support their effectiveness for treating adult atopic dermatitis. In summary, topical treatments like emollients, topical steroids, and calcineurin inhibitors are the mainstay of therapy for managing adult atopic dermatitis, according to the guidelines.

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