Intrathecal chemotherapy is a form of cancer treatment in which a doctor injects chemotherapy drugs into the cerebrospinal fluid. If cancer affects the central nervous system, your doctor may recommend intrathecal chemotherapy. A person can also receive other forms of chemotherapy, such as B. Oral, inhalation, and injection. During intrathecal chemotherapy, a healthcare professional injects chemotherapy drugs into the fluid around the spinal cord during a lumbar puncture or lumbar puncture. Your doctor may recommend intrathecal chemotherapy for more specific treatment of CNS itself. Intrathecal chemotherapy is performed to prevent cancer from entering the cerebrospinal fluid in other parts of the body and attacking cancer cells around the brain and spinal cord. If a person has any of these cancers, the doctor may recommend intrathecal chemotherapy to prevent cancer from spreading to the cerebrospinal fluid and cure cancer cells that have reached the central nervous system.

Regarding intrathecal chemotherapy, patients should discuss this process with their doctor. For cancers that have spread to the central nervous system, intrathecal chemotherapy is more effective than intravenous or oral chemotherapy. Doctors should be able to provide patients with more information about their specific prognosis. The doctor may recommend intrathecal chemotherapy for cancer patients that affect the central nervous system. This treatment may be the best option because the blood-brain barrier reduces the effectiveness of oral or intravenous chemotherapy. The systemic effects of intrathecal chemotherapy have been well documented, including leukopenia1,2 and tumor lysis syndrome. Blood flow with long-term cytotoxic levels. After reaching a significant concentration in the cerebrospinal fluid, the intrathecal drug can enter the systemic circulation through passive diffusion. This is the anatomical relationship between the spinal cord and bone marrow, especially its slices. Introducing intrathecal chemotherapy to treat and prevent tumor infiltration of the central nervous system.

The system is a wide-ranging practice and has been proven effective for various pathologies. Although the use of IT chemotherapy has been widely recognized by the scientific community, there are many aspects in practice, such as preparation methods and application technologies. This review selects articles with high clinical relevance, these articles are based on the development or description of the relevant practical aspects of preparing and executing IT treatment technology, have less experience with parabens and have no treatment-related Side effects. Has been described. Steering; however, there are reports that intravenous administration can cause allergic reactions. This risk, coupled with the scarce data used by IT, hinders the use of IT. There is no information on the method used to obtain monoclonal antibodies. And ready. For intrathecal administration; for intrathecal use, always use a preservative-free solvent in a sterile and pyrogen-free environment. It is necessary to logically consider preparation requirements20. The use of combined IT chemotherapy is a logical result because the use of combined systemic chemotherapy has been shown to increase effectiveness compared to a single administration of anticancer drugs. As mentioned above, the use of corticosteroids in combination with IT chemotherapy appears to have a positive effect on side effects; because simultaneous IT administration of corticosteroids reduces the risk of membrane irritation described by the use of methotrexate and ARAC alone78.