Premature ovarian insufficiency is the cessation of menstruation in women under the age of 40.  Also, there are elevated serum FSH levels of more than 25.  There are two separate occasions at least one month apart and there is concomitant low estradiol, E2 is less than 50 picogram, and amenorrhea for at least four months. It is right from the pediatrician to the geriatrics we can say not the geriatrics up to the age of 40 though it is.  It comes under the domain of pediatricians when they see transgender patients. The early patients with amenorrhea and have the problem of premature ovarian insufficiency. Gynecologists see these patients as secondary amenorrhea.  All the chemotherapists or chemotherapy or the cancer surgeon people or all those people. Also, the patient of premature ovarian insufficiency as well as all the endocrinal people and the infertility specialists.  Especially there come up with POI more and more and the menopause people also.  So the FSH more than 40 and then clinical hallmarks, sustained amenorrhea, infertility, hot flashes, vaginal atrophy, age less than 40 years and the number of primordial follicles, accelerated atresia, impaired follicular function and estrogen is less than 50 so these are the criteria when we say or blame someone that she is having a premature ovarian insufficiency.

All the chemotherapists or chemotherapy or the cancer surgeon people or all those people. Also the patient of premature ovarian insufficiency as well as all the endocrinal people and the infertility specialists.  Especially there come up with POI more and more and the menopause people also.  So the FSH more than 40 and then clinical hallmarks, sustained amenorrhea, infertility, hot flashes, vaginal atrophy, age less than 40 years and the number of primordial follicles, accelerated atresia, impaired follicular function and estrogen is less than 50 so these are the criteria when we say or blame someone that she is having a premature ovarian insufficiency.

Primary there are the chromosomal anomalies, Turner syndrome, Fragile X, autoimmune disease, hypothyroidism, Addison’s, myasthenia gravis, enzyme deficiency, galactose, and 17-alpha hydroxylase deficiency. So, the POI comes in all the domains right from adolescent people to the endocrine things and the second there can be chemotherapy or radiotherapy or there is infection especially tuberculosis, mumps, malaria, and varicella.  So the tuberculosis is also very, very endemic in this country, and the patients of POI off and on.

You can find out more details by enrolling in premature ovarian insufficiency by Dr. Kawita Bapat (MBBS, MS, FICOG) here, https://docmode.org/premature-ovarian-insufficiency-dr-kawita-bapat/