Gut Microbiome’s Direct Role in GERD Pathogenesis

Research demonstrates gut microbiome dysbiosis actively contributes to GERD through three key mechanisms: molecular pathways (Toll-like receptor activation, COX-2 upregulation), immune system modulation, and disrupted gastrointestinal motility. The microbiome-gut-brain axis further connects microbial changes to GERD by altering brain-gut peptide secretion, which regulates both visceral sensitivity and digestive tract dynamics. These findings establish the microbiome as a significant factor in GERD development.

References: https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1558414/full