Expert Recommendations for Short-Term PPI Use in Gastrointestinal Disorders

Proton pump inhibitors (PPIs) are widely used for managing acid-related gastrointestinal conditions. Their effectiveness depends on proper indication, dosing, and treatment duration. To support evidence-based use in clinical practice, a panel of experts from the Asociación Mexicana de Gastroenterología (AMG) developed doctor-friendly recommendations for short-term PPI therapy. They recommend standard-dose PPIs for 4 weeks in cases like nonerosive reflux disease and functional dyspepsia, and 4–8 weeks for gastric ulcers. Duodenal ulcers need 4 weeks. For GERD, mild esophagitis requires standard-dose and severe cases double-dose PPIs for 8 weeks. Double-dose PPIs are advised for H. pylori eradication, and high-dose PPIs for GI bleeding or ICU stress ulcer prevention.

References: https://www.sciencedirect.com/science/article/pii/S2255534X25000209?via%3Dihub