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Increased CV risk in type 2 diabetes without CVD

Increased CV risk in type 2 diabetes, chronic kidney disease by the data published in Diabetic Medicine. Data missing were accounted for by multiple imputations, the CV risk in type 2 diabetes and death in people with chronic kidney disease was equal to or greater than that in people with cardiovascular disease. 

 Risk factors such as obesity, hypertension and dyslipidemia were more common in people without cardiovascular disease than in people with cardiovascular disease, possibly since people who had previously had events put more emphasis on prevention. There are. These results highlight the need to manage cardiovascular risk. They stress the need to identify the factors of early onset of type 2 diabetes in all people and to identify those who may benefit from treatments that reduce the risk of cardiovascular disease. 

 Low CV risk in type 2  diabetes without cardiovascular disease. The researchers made retrospective observations using data from the UK GOLD Clinical Practice Research Datalink database. The analysis included adults with type 2 diabetes who received first- and second-line drug therapy to lower blood sugar from 2001 to 2016. 

 To identify groups at high risk for cardiovascular disease, we analyzed nine risk factors: gender, age, obesity, hypertension, dyslipidemia,  smoking, hyperglycemia, duration of diabetes and chronic renal failure. 3 major adverse cardiovascular events, a combination of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke; 3-point MACE and extended MACE including hospitalization for angina, heart failure or coronary reperfusion; And they all-cause death.

People with type 2 diabetes and without CVD had a lower risk of 3-point MACE, dilated MACE and all causes of death. The 3-point risk of  MACE increased with the number of risk factors in people without CVD. Of the nine risk factors, CRF was associated with the highest risk of 3-point MACE and extended MACE in patients without cardiovascular disease. Additionally, people without cardiovascular disease or CRF had a higher risk of death from any cause than people with cardiovascular disease. 

Analysis  shows that nephropathy and other microvascular diseases collectively have a significant impact on the risk of cardiovascular disease  in people with type 2 diabetes. We have identified risk factors that may help isolate patients with type 2 diabetes without cardiovascular disease, in particular modifiable risk factors that reduce cardiovascular risk due to a high risk of cardiovascular events and control hypoglycaemic therapy. 

Diseases representing% to 50%, 3.4 versus 26% of controls with normal renal function. In more than 70 studies involving patients with chronic renal failure without dialysis, modification of classic and unclassical cardiovascular risk factors such as hypertension, diabetes and dyslipidemia moderated the effect of chronic renal failure on the patient risk. Current knowledge of cardiovascular disease in chronic renal failure patients, clinical outcomes and treatment options for cardiovascular disease in chronic renal failure patients. For reasons of space, special situations such as extrarenal vasculitis lesions or the association between autosomal dominant polycystic kidney disease and intracranial, aortic or coronary aneurysms or vascular abnormalities such as aortic dissection are not processed by the  Kidney Disease Outcome Quality.


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