A combined set of clinical and biological variables could accurately predict polyp recurrence and severity among patients who have had endoscopic sinus surgery, according to a study published in The Journal of Allergy and Clinical Immunology. The study involved 94 patients (median age, 49.5 years; 58.5% men) with CRSwNP who had endoscopic sinus surgery (ESS) with nasal polyp collection at Northwestern Memorial Hospital between 2012 and 2017. This prediction model may help clinicians determine which patients with chronic rhinosinusitis with nasal polyps may derive the greatest benefits from adjunctive therapies to prevent polyp recurrence, the researchers wrote in the study. Prior to this study, it was unclear what the implications of polyp regrowth were on patient symptoms and on overall disease burden.