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Differences in histology of skin lesions in allergic asthma

A team of researchers led by Dr Jacob Howran at McMaster University has identified distinct differences in the histology of skin lesions of patients with allergic asthma, with or without the presence of atopic dermatitis. The research, presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting 2022, showed that skin lesions from patients with atopic dermatitis had more spongiosis (P = 0.04) and lymphocyte infiltration (P <0.01) compared to the skin lesions from the patients without atopic dermatitis. The team, which examined 17 patients with moderate-to-severe atopic dermatitis and 14 patients with allergic asthma but no history of atopic dermatitis and 15 healthy controls, also observed that lymphocytic infiltration of unaffected skin was also higher in the atopic dermatitis cohort compared to the control group (P <0.01) and patients with allergic asthma (P = 0.03). 



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