Dupilumab effective for EoE too when used for AD, asthma

Administering dupilumab for other atopic conditions such as atopic dermatitis (AD) and asthma in patients who also have eosinophilic esophagitis (EoE) resulted in improved EoE symptoms. A recent study consisting of a retrospective chart review of all patients at Children’s Hospital of Philadelphia and Rady Children Hospital in San Diego, analysed 45 patients among which 47percent had 4 atopic conditions wherein EoE was defined by greater than or equal to 15 eosinophils/high-power field (eos/hpf) in esophageal biopsies. Importantly, out of 41 patients treated with dupilumab for an approved indication, 39 met the criteria for clinical improvement. At the same time, 28 patients saw their EoE symptoms improve and 24 patients showed complete resolution of symptoms and several of them were able to reduce their EoE treatment medications.

Content by Future Medicine

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