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Omicron-L452R could be the most risky SARS Cov-2 variant

Even as the Omicron variant of SARS CoV-2 exhibited diminished fusogenicity and pathogenicity compared with the Delta variant and the parental virus, a recent study investigating the effect of L452R, a mutation seen in the Delta variant, on the fusogenicity of the Omicron variant, and published on, demonstrated that the combination (Omicron-L452R) exerted markedly enhanced fusogenicity and thereby it could be one of the most riskier variants.  This is because the essential role of the L452R mutation in SARS-CoV-2 was fusogenicity and infectivity. 

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