During the week of 28 February through 6 March 2022, the number of new COVID-19 cases and deaths has continued to decline globally by 5 percent and 8 percent respectively, as compared to the previous week. Across the six WHO regions, over 10 million new cases and over 52 000 new deaths were reported. As of 6 March 2022, over 433 million confirmed cases and over 5.9 million deaths have been reported globally. At the regional level, while the Western Pacific Region continues to report an increase (+46%) in the number of new weekly cases, all other regions reported decreases. The number of new weekly deaths increased in the Western Pacific (+29%) and the Eastern Mediterranean (+2%) Regions, while decreases were reported by the African Region (-39%), Europe Region (-15%), the Region of the Americas (-9%) and South-East Asia Region (-3%).